Buffalo at Colorado 8:00 PM ET
The injury bug has bitten the Colorado Avalanche hard but they are biting back as they host the Buffalo Sabres on Wednesday. Colorado is missing its third-highest goal scorers in Mikko Rantanen and Nazem Kadri, and No. 1 goaltender Philipp Grubauer among others but has won three straight and is 11-3-1 in its last 15 games as the club tries to utilize a different style of play without some of its offensive pop.
Edmonton at Vegas 10:30 PM ET
The Pacific Division-leading Vegas Golden Knights put their season-high six-game win streak on the line Wednesday when they open a four-game homestand against the Edmonton Oilers. Both teams are coming off overtime contests in Anaheim with Vegas securing a 6-5 victory Sunday and Edmonton leaving with a 4-3 setback on Tuesday.
Pittsburgh at Los Angeles 10:30 PM ET
The Pittsburgh Penguins added more experienced depth up front at the trade deadline Monday and look to snap a three-game losing streak when they begin a tour of California on Wednesday night against the Los Angeles Kings. The Penguins, who also visit Anaheim and San Jose later in the week, picked up future Hall of Famer Patrick Marleau among three forwards in two deals.